Research Training Fellow
My interest in medical research first began during my foundation training, has further developed throughout my Orthopaedic Specialty training and from my involvement with CORNET, the Collaborative Orthopaedic Research Network. I have completed an MSc in Musculoskeletal Science at University College London which stirred my interest in ageing and in particular the potential of utilising tissue engineering for novel therapeutics in the treatment of Osteoarthritis.
Osteoarthritis is a significant burden on health resources globally. Novel approaches are needed to tackle the increased morbidity caused by this disease and provide alternative solutions to those currently available for terminal disease; such as joint replacement surgery. Tissue engineering approaches are needed to provide biological treatments for Osteoarthritis without the drawbacks of using inorganic materials. CRISPR-Cas9 technology has opened up new avenue to control cellular function and revolutionise tissue engineering approaches to cartilage generation.
The title of my DMT-funded research training fellowship project is ‘Enhancing chondrogenesis using CRISPR-cas9’. Through my PhD, under the supervision of Professor David Young, Professor David Deehan, Dr Matt German and Dr Oana Bretcanu, I aim to see if CRISPR-cas9 gene modulation techniques can be used to enhance chondrogenesis using mesenchymal stem cells. This research is vital on the long-term trajectory for developing biological joint cartilage replacement solutions for the treatment of Osteoarthritis.