Understanding the mechanisms of age-related disease

Grayscale close-up of a human eye

Using genetic data to understand the causes of age-related macular degeneration

When investigating diseases of ageing and their causes, it can be very difficult, time-consuming and expensive to conduct randomised controlled trials. Instead, Drs Reecha Sofat and Valerie Kuan are using a technique called Mendelian Randomisation to understand the underlying risk factors for the sight loss condition age-related macular degeneration, shedding light on new ideas for prevention and treatment.

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How does ageing change our cartilage?

We know that the spongy cartilage between bones changes during ageing and osteoarthritis, but it’s not clear how these processes are related. By comparing what’s happening in cartilage cells at a molecular level during ageing and osteoarthritis, Dr Simon Tew is gathering insights that will pave the way for future therapies.

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