5-minute Fellowships: Kieran Bowden – Targeting neutrophil cell death as a treatment for multimorbidity
Kieran Bowden is a PhD student at the University of Sheffield funded by the Dunhill Medical Trust-Healthy Lifespan Institute Doctoral Training Programme. Kieran studied biomedical sciences at the University of Hull as an undergraduate before going on to complete a master’s in molecular medicine at the University of Sheffield, and his work focuses on targeting neutrophil cell death for treating multimorbidity.
Multimorbidity, defined as the presence of two or more chronic conditions, is a growing concern, particularly in older people. In his talk, Kieran highlights the prevalence of chronic inflammatory diseases and the limited success of current treatments. To tackle this problem, Kieran is investigating the use of the drugs Neratinib and Ruboxystaurin to target neutrophil cell death and potentially resolve chronic inflammation.
Kieran discusses the promising preliminary results from his research so far. He shows how Ruboxystaurin significantly reduces neutrophil extracellular trap (NET) formation, which causes chronic inflammation, and how Neratinib induces apoptosis in neutrophils. He also details his plans for future research using both single disease and combined mouse models for COPD and atherosclerosis, to assess whether these drugs can be used to treat multimorbidity.
Watch the recording
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Meet the speakers
Keiran studied biomedical sciences at the University of Hull as an undergraduate before going on to complete a master’s in molecular medicine at the University of Sheffield. Kieran is now a PhD student based at the University of Sheffield Healthy Lifespan institute and is going into his final year.