Underlying ageing mechanisms

Frozen shoulder is a painful and disabling condition, but how it develops remains unknown. Read how Hamez Gacaferi’s work is starting to unravel this mystery.

Recovering from a stroke is hard enough yet many patients go on to get an infection, sometimes months into their recovery. For some of these patients, this can lead to more disability. Dr Rebecca Trueman, at the University of Nottingham, led a pilot study to uncover new targets that could help to protect recovering stroke patients.

Despite affecting most people over the age of 50, we don’t really know why age-related muscle loss happens. Dr Katarzyna Goljanek-Whysall, now Senior Lecturer at the National University of Ireland, Galway but who led the work when at the University of Liverpool, thinks that oxidised microRNAs could be an important clue to unlocking better treatments for declining muscle function as we get older.

To understand how brains age, researchers often study short-lived rats and mice. Another rodent, the naked mole rat, lives for decades and ages healthily. Professor Ewan St. John Smith and his team are examining this unusual animal to see whether its unique ageing biology can unlock new ways to treat and cure neurodegenerative diseases.

Published November 2020 When we talk about ageing, people often highlight the external signs. But there’s plenty more going on inside our bodies as we get older. Worn-out senescent cells accumulate within our tissues, pumping out inflammatory chemicals – …

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When investigating diseases of ageing and their causes, it can be very difficult, time-consuming and expensive to conduct randomised controlled trials. Instead, Drs Reecha Sofat and Valerie Kuan are using a technique called Mendelian Randomisation to understand the underlying risk factors for the sight loss condition age-related macular degeneration, shedding light on new ideas for prevention and treatment.

We know that the spongy cartilage between bones changes during ageing and osteoarthritis, but it’s not clear how these processes are related. By comparing what’s happening in cartilage cells at a molecular level during ageing and osteoarthritis, Dr Simon Tew is gathering insights that will pave the way for future therapies.